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Plasmodium berghei: T cell-dependent autoimmunity

Identifieur interne : 003814 ( Main/Exploration ); précédent : 003813; suivant : 003815

Plasmodium berghei: T cell-dependent autoimmunity

Auteurs : Lambert G. Poels [Pays-Bas] ; Catherine C. Van Niekerk [Pays-Bas] ; Virag Van Der Sterren-Reti [Pays-Bas] ; Christoph Jerusalem [Pays-Bas]

Source :

RBID : ISTEX:C9595171E836E861A188017CA3593E94B7031DF7

English descriptors

Abstract

Abstract: Plasmodium berghei infection in euthymic mice induced the formation of smooth muscle autoantibodies (SMA) persisting in cured immune mice. Antinuclear antibodies (ANA) were found in challenged hyperimmune mice, but not in acutely infected mice. The autoantibodies were not detected in infected and cured athymic, nude mice, and are therefore T-cell dependent. No evidence for other autoantibodies was obtained. Parallel studies on deposited immune complexes in renal glomeruli served as control for any absence of autoantibodies.

Url:
DOI: 10.1016/0014-4894(80)90061-2


Affiliations:


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Le document en format XML

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<term>Autoantibody</term>
<term>Autologous erythrocytes</term>
<term>Berghei</term>
<term>Berghei infection</term>
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<term>Chloroquine</term>
<term>Chloroquine therapy</term>
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<term>Murine malaria</term>
<term>Negative findings</term>
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<term>Other autoantibodies</term>
<term>Parasitic</term>
<term>Parasitic antigens</term>
<term>Parasitology</term>
<term>Plasmodium</term>
<term>Plasmodium berghei</term>
<term>Plasmodium berghei infection</term>
<term>Poels</term>
<term>Polyclonal activation</term>
<term>Renal</term>
<term>Renal glomeruli</term>
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<term>Serum samples</term>
<term>Smooth muscle autoantibodies</term>
<term>Thymocytes</term>
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<div type="abstract" xml:lang="en">Abstract: Plasmodium berghei infection in euthymic mice induced the formation of smooth muscle autoantibodies (SMA) persisting in cured immune mice. Antinuclear antibodies (ANA) were found in challenged hyperimmune mice, but not in acutely infected mice. The autoantibodies were not detected in infected and cured athymic, nude mice, and are therefore T-cell dependent. No evidence for other autoantibodies was obtained. Parallel studies on deposited immune complexes in renal glomeruli served as control for any absence of autoantibodies.</div>
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